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Interleukin-6 (IL-6) and interleukin-1β (IL-1β), known as multifunctional cytokines with high biological activity, play an important role in physiological and pathological responses such as inflammation, immune response and even tumors. There have been multiple polymorphism loci found in IL-6 gene and IL-1β gene. The aim of this study is to investigate the relationship between IL-6-643 (C/G) and IL-1β-31 (C/T) polymorphisms and lung cancer risk among female non-smokers and explore the interaction effects on lung cancer risk between this two polymorphisms and potential risk factors such as cooking oil fumes exposure and history of tuberculosis.

[Association of genetic polymorphisms in IL-6 and IL-1β gene with risk of lung cancer in female non-smokers].