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Worldwide a large number of medicinal plants is consumed by people for the therapy of various pathologies. Genotoxicity tests with plants have increased concomitantly with the misuse of medicinal plants for therapeutic use by the population. However, most of these species has not been sufficiently evaluated for the presence of compounds with mutagenic potential in its composition. This work aimed to evaluate the _ genotoxic in vitro potential of the aqueous extract of Luffaoperculata and determine the potential kidnapper of DPPH radical in order to determine a safe concentration for human consumption. Concentrations of 1, 5, 10, 50, 100, 500 and 1000μg / mL were tested. The number of metaphases and chromosome breaks, as well as the percentage of DPPH radical kidnapping activity were evaluated. At the concentration of 1mg / ml, the absence of chromosome breakage was observed. All concentrations tested showed DPPH radical kidnapping activitywith a greater activity in the concentration 1000μg / mL. Thus, it was found that the concentration of 1mg / ml has no mutagenic effect on peripheral blood mononuclear cells in vitro, therefore, it is considered a safe dose at the chromosomal level.

EFEITO GENOTÓXICO IN VITRO DO EXTRATO AQUOSO DE LUFFA OPERCULATA SOBRE CÉLULAS MONONUCLEARES DE SANGUE PERIFÉRICO 1 GENOTOXIC EFFECT IN VITRO OF AQUEOUS EXTRACT OF LUFFA OPERCULATA ABOUT PERIPHERAL CELLS IN BLOOD MONONUCLEAR 1