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Review question / Objective: One third of patients may have post-stroke depression after a stroke. Poststroke depression seriously affects rehabilitation outcome, quality of life and mortality of stroke patients. Data on preventive treatment of fluoxetine for post-stroke depression in this setting are inconsistent. The purpose of this systematic review was to explore the efficacy and acceptability of fluoxetine for early antidepressant therapy in stroke patients, so as to better provide evidence-based medical evidence for clinical practice. To this end, the systematic review to be considered will address the following issues: P: stroke patients; I: Treatment interventions included: fluoxetine (Prozac), control group: conventional treatment, plus placebo or no other intervention; O: Primary outcome: incidence of PSD, secondary outcome: Hamilton Scale, neurological dysfunction, daily living ability, mortality, incidence of adverse reactions; S: This review includes only randomized controlled studies.

Is fluoxetine necessary for preventive treatment of post-stroke depression in stroke patients? A meta-analysis of randomized controlled trials