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Review question / Objective: The aim of this systematic review is to valuate the efficacy and safety of acupuncture combined with Chinese herbal medicine in the treatment of primary liver cancer inform clinical practice. To this end, the proposed systematic review will address the following question: Which is the best choice to effective in improving The short-term curative effect is effective, the quality of life is stable, and the survival rate of patients is six months/one year in patients with primary liver cancer, acupuncture combined with Chinese herbal medicine or the best supportive treatment? Information sources: We will search the following databases: PubMed, Web of Science, Embase, AMED, Cochrane Library, CNKI, VIP, CBM, and Wanfang. Additionally, we will manually search all reference lists from relevant systematic reviews to find other eligible studies. We will exclude all conference records, reviews, meta-analyses, newspapers, guides, letters and other documents. When the full text or the required information in the analysis process was missing, the author of the studies was contacted for data.

Efficacy and safety of acupuncture combined with Chinese herbal medicine in the treatment of primary liver cancer: A protocol for systematic review and meta-analysis