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OBJECTIVE: The objective of this study was to determine the frequency of complete and partial remission after 2 courses of hyper CVAD regimen in newly diagnosed patients of acute lymphoblastic leukemia (ALL).MATERIAL AND METHODS: This study was conducted on 100 patients of ALL presenting to the oncology department of Jinnah Hospital, Lahore and fullling the inclusion criteria from 01-012016 to 30-12-2016. Patients were undergone treatment with hyper CVAD regimen according to the standard protocol. Complete or partial remission rate was checked after 2 session of hyper CVAD regimen. CT scan (chest and abdomen) was performed for conrmation of extramedullary disease. RESULTS: The mean age of study population was 35.68 ± 8.69 years. There were 48% male patients while female patients were 52%. Complete remission was present in 72% patients. Partial remission was present in 24% patients. There was no signicant association between complete remission and age (p-value=0.497). No signicant association was found between partial remission and age (p-value=0.103). Signicant association was found between partial remission and complete remission with gender having p-value=0.001 and 0.01 respectively. CONCLUSION: The frequency of complete and partial remission after 2 courses of hyper CVAD regimen in newly diagnosed patients of ALL was 72% and 24% respectively. Eect modiers have no signicant inuence except gender.

journal of university medical and dental college

FREQUENCY OF REMISSION AFTER TREATMENT WITH HYPER CVAD PROTOCOL IN NEWLY DIAGNOSED PATIENTS OF ACUTE LYMPHOBLASTIC LEUKEMIA PRESENTING TO JINNAH HOSPITAL LAHORE