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This study aimed to quantify and characterize the use of automated health care databases for pharmacoepidemiology research over the past decade. To identify studies on drug safety, drug utilization, validation of database data, and disease epidemiology conducted in databases, we reviewed abstracts accepted at the International Conference of Pharmacoepidemiology in 2000 and 2011. The total number of abstracts doubled from 389 in 2000 to 806 in 2011. Abstracts on database studies comprised 35.7 percent (139 of 389) of all abstracts in 2000 and 44.6 percent (360 of 806) in 2011. The most common study objective in both years was drug safety evaluation. Abstracts on validation of database data increased from 2 to 39. Multiple-database abstracts increased from 9 to 43. The number of countries contributing to database abstracts increased from 14 to 22, with the increase primarily in Europe and the Asia-Pacific region. The findings suggest that the use of health care databases in pharmacoepidemiologic research is growing in many countries. The different types of database studies and the number of studies conducted using multiple databases are also increasing. This suggests that larger study populations and greater collaboration among investigators are becoming more common.

Changes in the landscape of health care database research from 2000 to 2011