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A recent find of a Marasmius species in Northern Thailand led to the isolation of five unprecedented derivatives of the carotane antibiotic fulvoferruginin ( 1 ), fulvoferruginins B-F ( 2 - 6 ). The structures of these sesquiterpenoids were elucidated using HRESIMS, 1D and 2D NMR, as well as CD spectroscopy. Assessing the bioactivity, fulvoferruginin emerged as a potent cytotoxic agent of potential pharmaceutical interest.

Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai Marasmius sp.