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Three new tetronate-class polyketides, nomimicins B, C, and D, along with nomimicin, hereafter named nomimicin A, were isolated from the culture extract of Actinomadura sp . AKA43 collected from floating particles in the deep-sea water of Sagami Bay, Japan. The structures of nomimicins B, C, and D were elucidated through the interpretation of NMR and MS analytical data, and the absolute configuration was determined by combination of NOESY/ROESY and ECD analyses. Nomimicins B, C, and D showed antimicrobial activity against Gram-positive bacteria, Kocuria rhizophila and Bacillus subtilis , with MIC values in the range of 6.5 to 12.5 μg/mL . Nomimicins B and C also displayed cytotoxicity against P388 murine leukemia cells with IC 50 values of 33 and 89 μM, respectively.

Nomimicins B–D, new tetronate-class polyketides from a marine-derived actinomycete of the genus Actinomadura