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A wide range of derivatives with new pyrido[2,1- a ]pyrrolo[3,4- c ]isoquinoline skeleton was synthesized by free-radical intramolecular cyclization of  o -bromophenyl-substituted pyrrolylpyridinium salts using the (TMS) 3 SiH/AIBN system. The cyclization provides generally good yields of pyrido[2,1- a ]pyrrolo[3,4- c ]isoquinoline hydrobromides having no additional radical-sensitive substituents. The free bases can be obtained from the synthesized hydrobromides in quantitative yield by basification at room temperature. The selectivity control of intramolecular arylation was achieved by replacing the halogen: the use of 1-(2-( ortho -bromophenyl)-4-( ortho -iodophenyl)pyrrol-3-yl)pyridinium bromide makes it possible to obtain a monocyclization product, and the bicyclization product from the dibromo derivative. The procedure is also applicable to obtain 3-arylpyrido[2,1- a ]pyrrolo[3,2- c ]isoquinoline derivatives including 2-unsubstituted skeletons that are inaccessible via Pd-catalyzed cyclization.

Free-radical cyclization approach to polyheterocycles containing pyrrole and pyridine rings