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A detailed chemical investigation of the South China Sea soft corals Clavularia viridis and Lemnalia flava yielded four new halogenated laurane-type sesquiterpenoids, namely, isobromolaurenisol ( 1 ), clalaurenol A ( 2 ), ent -laurenisol ( 3 ), clalaurenol B ( 4 ), and the new aromadendrane-type sesquiterpenoid claaromadendrene ( 6 ), together with three known sesquiterpenoids ( 5 , 7 , and 8 ). Their structures were determined by extensive spectroscopic analysis and by comparison with the previously reported analogues. In a bioassay, compounds 1 , 2 and 4 exhibited interesting inhibitory activities in vitro against PTP1B and NF-κB.

New sesquiterpenoids from the South China Sea soft corals Clavularia viridis and Lemnalia flava