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A water-soluble 2,2'-biphen[4]arene (2,2'-CBP4) containing eight carboxylato moieties was synthesized and characterized. Its complexation behavior towards two alkaloids, palmatine ( P ) and berberine ( B ), was investigated by means of fluorescence and 1 H NMR spectroscopy in aqueous phosphate buffer solution (pH 7.4). In the presence of 2,2'-CBP4, 1 H NMR signals of P and B displayed very large upfield shifts, indicating the formation of inclusion complexes with strong binding affinities. Fluorescence titration experiments showed that P and B exhibited dramatic fluorescence enhancement of more than 600 times upon complexation with 2,2'-CBP4. Particularly, the fluorescence intensity is strong enough to be readily distinguished by the naked eye. Although the two guests have similar structures, the association constant of B with 2,2'-CBP4 ( K  a = (2.29 ± 0.27) × 10 6 M -1 ) is 3.9 times larger than that of P ( K  a = (5.87 ± 0.24) × 10 5 M -1 ).

Synthesis of a water-soluble 2,2′-biphen[4]arene and its efficient complexation and sensitive fluorescence enhancement towards palmatine and berberine