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Background Previous studies demonstrated that vagus nerve stimulation (VNS) is an effective therapy for drug‐resistant epilepsy. Acupuncture is also used to treat epilepsy. This study was designed to examine the safety and effectiveness of transcutaneous auricular vagus nerve stimulation (ta‐VNS) for patients with drug‐resistant epilepsy. Methods A total of 50 volunteer patients with drug‐resistant epilepsy were selected for a random clinical trial to observe the therapeutic effect of ta‐VNS. The seizure frequency, quality of life, and severity were assessed in weeks 8, 16, and 24 of the treatment according to the percentage of seizure frequency reduction. Results In the pilot study, 47 of the 50 epilepsy patients completed the 24‐week treatment; three dropped off. After 8‐week treatment, six of the 47 patients (12%) were seizure free and 12 (24%) had a reduction in seizure frequency. In week 16 of the continuous treatment, six of the 47 patients (12%) were seizure free; 17 (34%) had a reduction in seizure frequency. After 24 weeks' treatment, eight patients (16%) were seizure free; 19 (38%) had reduced seizure frequency. Conclusion Similar to the therapeutic effect of VNS, ta‐VNS can suppress epileptic seizures and is a safe, effective, economical, and widely applicable treatment option for drug‐resistant epilepsy. (ChiCTR‐TRC‐10001023)

An alternative therapy for drug-resistant epilepsy: transcutaneous auricular vagus nerve stimulation