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Do word frequency and case mixing affect different processing stages in visual word recognition? Some studies of online reading have suggested that word frequency affects an earlier, perceptual-encoding stage and that case mixing affects a later, central decision stage (e.g., Reingold, Yang, &amp; Rayner, Journal of Experimental Psychology: Human Perception and Performance 36:1677-1683 2010); others have suggested otherwise (e.g., Allen, Smith, Lien, Grabbe, &amp; Murphy, Journal of Experimental Psychology: Human Perception and Performance 31:713-721 2005; Besner &amp; McCann, 1987). To determine the locus of the word frequency and case-mixing effects, we manipulated word frequency (high vs. low) and case type (consistent lower case vs. mixing case) in a lexical-decision paradigm. We measured two event-related-potential components: the N170 (an early peak occurring 140-240 ms after stimulus onset, related to structural encoding) and the P3 (a late peak occurring 400-600 ms after stimulus onset, related to stimulus categorization). The critical finding was that the N170 amplitude was sensitive to case mixing, but the P3 amplitude was sensitive to word frequency and lexicality. These results suggest that case mixing affects an earlier processing stage than does word frequency, at least with respect to lexical-decision processes.

Electrophysiological evidence of different loci for case-mixing and word frequency effects in visual word recognition