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Twenty pregnant female rats were each given one injection of (1) 1.5cc/kg body weight of a 1:1000 solution of adrenalin chloride, (2) 3.0mg/kg body weight of a 0.9mg/l.0cc solution of d-amphetamine sulfate, or (3) 1.5cc/kg body weight of distilled water. Injections were administered intraperitoneally either between 6 and 9 days post-conception, during which time the fetal stomach and intestine are developing, or between 12 and 15 days post-conception. Following normal rearing, offspring were subjected to immobilization stress, with pre- and post-measures of emotionality, following which they were assayed for ulcers. The results indicate modified emotionality as a function of the prenatal treatments, and a significantly higher frequency of ulceration in those Ss whose mothers had been injected with adrenalin at the time of the fetal stomach development.

The effects of prenatal injections of adrenalin chloride and d- amphetamine sulfate on subsequent emotionality and ulcer-proneness of offspring