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It has been suggested that the coordination of complex sequences of behavior requires normal nigrostriatal function. A previous study showed that kainic acid lesions of the corpus striatum can disrupt the performance of natural, untrained stereotyped sequences (syntactic chains), which occur regularly during normal rodent grooming. In this study, intranigral injections of 6-OHDA were used to destroy nigrostriatal dopamine projections in order to deplete the striatum of dopaminergic inputs. Striatal dopamine depletion was found to disrupt the effective completion of syntactic grooming chains. Syntactic chain disruption was correlated with the aphagia that follows dopamine depletion. These data were compared with those from previous studies of chain completion after striatal damage, after sensory deafferentation, and after decerebration at various levels of the brainstem. These comparisons indicated that the loss of either dopamine projections or intrinsic striatal neurons produced equivalent disruption of syntactic grooming chains. It also showed that loss of either component of the nigrostriatal system disrupted chaining to a degree equal to that produced by loss of the entire forebrain. These results suggest that the integrity of nigrostriatal systems is crucial to forebrain implementation of this stereotyped sequence.

Substantia nigra 6-OHDA lesions mimic striatopallidal disruption of syntactic grooming chains: A neural systems analysis of sequence control