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Sodium chloride (NaCl) consumption (3 × 10−1 M) by and NaCl and potassium chloride (KCl) preferences of Long-Evans rats and Egyptian spiny mice were assessed prior to, during, and after maintenance on hydrochlorothiazide (HCTZ) or control procedures. The rats demonstrated increased sodium salt consumption and lowered NaCl preference thresholds and similar, although less robust, changes were observed for the spiny mice. No changes in salt-taste sensitivity were observed for the control animals.

Salt-taste responsivity in Long-Evans rats and Egyptian spiny mice treated with hydrochlorothiazide