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Preoptic and anterior hypothalamic injections of three concentrations of atropine sulfate in the cat resulted in a dose-related decrease in food and water intake. Water intake was more effectively inhibited by atropine than was food intake, which was suppressed only at the highest concentration employed. Results were interpreted as being consistent with behavioral effects of hypothalamic lesions and somewhat less related to “chemically coded” behaviors in the cat.

Hypothalamic anticholinergic inhibition of eating and drinking in the cat