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African mouthbreeding fish were trained to strike a bar on a VR2 schedule of reinforcement. Over a 10-day period, operant rate of responding was measured on 5 days, randomly interspersed with 5 days on which light (CS) was followed by shock (US) on 10 trials per day in the same environment. The CS was later introduced during operant responding; this resulted in suppression of operant responding. Subsequent infection of reserpine attenuated suppression of operant responding, but saline injection did not. These results probably were a direct function of reserpine administration on rate of recovery of responding following CS onset rather than an indirect function of baseline response rate or “;sedation effects.”

Reserpine and conditioned suppression in the fish Tilapia h. macrocephala