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Rats previously trained on a brightness discrimination habit, incline plane discrimination problem, maze habit, or an active avoidance conditioned response showed significant retention deficits following bilateral electrolytic lesions to the entorhino-subicular area. It would appear that the entorhino-subicular area must be included within the “general memory system” (along with the brainstem reticular formation) by virtue of its contribution to the expression of a wide variety of learned responses.

Entorhino-subicular lesions: Amnestic effects on an assortment of learned responses in the white rat