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Rats with permanently implanted intracranial electrodes were trained in a shuttlebox to escape from intermittent electrical stimulation of the ventromedial hypothalamus. Their latency to escape was measured under different degrees of food deprivation (0, 21, and 45 h). Latency was found to decline with increasing deprivation. It is argued that this finding is evidence against the hypothesis that the structure acts as a “satiety center” in the control food intake.

The effect of food deprivation on escape from electrical stimulation of the VMH