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Albino rats (N = 18) received daily yeast RNA (160 mg/kg, IP) or saline injections from age 31 days to 73 days, with Hebb-Williams problems presented one per day on the last 12 days. There was no general facilitation from this manipulation but a Problems by Injection interaction (p <.05) indicated that the injection led to better performance on some problems, with a suggestion (r = +.33) that the degree of facilitation was related to problem difficulty. These data indicate that the injected substance does have an effect on complex problem-solving processes in distinction to some past conclusions that only general stimulation effects result.

Reagent grade yeast RNA injections and rat performance on the Hebb-Williams maze