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Two clinical syndromes, anorexia nervosa and the Kleine-Levin syndrome, are reviewed and a neuroendocrine basis for each is proposed. The disturbances in food intake, appetite, activity, sleep, hormonal levels, and thermoregulation seen in anorexia nervosa are shown to be similar to the physiological effects of estrogen, whereas the opposite disturbances of the same functions that are present in Kleine-Levin patients are found to be producible with androgens. Hypothalamic hypersensitivity to sex steroids, arising from incomplete hypothalamic maturation during puberty, is postulated as a primary cause of the symptoms of both disorders.

A possible neuroendocrine basis of two clinical syndromes: Anorexia nervosa and the Kleine-Levin syndrome