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Subjects from two strains of mice, C57BL/6J and DBA/2J, were either trained in a passive avoidance task or served as shock controls by receiving footshock at the same time as animals being trained. DBA/2J mice reached the learning criterion significantly faster than C57BL/6J mice. Latencies to leave the “safe” area on the first trial were not significantly different between the two strains. Subsequent analyses of the results of the spectrophotofluorometric assay of norepinephrine and serotonin in the hypothalamic and hippocampal brain regions revealed two effects. First, hippocampal serotonin was higher in DBA/2J mice compared to C57BL/6J mice. Secondly, hypothalamic norepinephrine was higher in DBA/2J mice trained for passive avoidance than in DBA/2 J mice that served as shock controls. The results suggest that the higher levels of hippocampal serotonin in DBA/2J mice compared to C57BL/6J mice may predispose the former strain to show better passive avoidance performance under specified circumstances. The observed differences in norepinephrine may have resulted from an interaction between serotonin levels and exposure to the present learning situation.

physiological psychology

The influence of mouse genotype on passive avoidance learning and subsequent concentrations of norepinephrine and serotonin in the hypothalamus and hippocampus