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Acquisition of knowledge about the chemical senses might be hastened if chemicals or techniques that permitted stimulation of either the common chemical sense, mediated by the trigeminal nerve, or the sense of smell, mediated by the olfactory nerve without concomitant stimulation of the other sense, were used. Flowing the nonodorized output of an olfactometer into one naris of subjects while velopharyngeal closure was maintained produced effluent flow from the contralateral naris. To prevent odorous molecules from reaching the olfactory epithelium, the contralateral naris was stimulated by applying diluted and undiluted chemical solutions directly to the septal squamous epithelium downstream from the olfactory mucosa. A series of five geometric dilutions of three chemicals and one saturated solution of a fourth were used. The weakest dilution of each chemical was an adequate olfactory stimulus. Two were known trigeminal stimulants (acetic acid and butanol), and two were rated low in trigeminal stimulatory capacity (phenethyl alcohol and vanillin). The results showed that this method was useful in determining the trigeminal threshold for some chemicals. When this method was used, saturated aqueous solutions of vanillin and phenethyl alcohol were clearly not detectable by the trigeminal receptors. The application of the undiluted vanillin and phenethyl alcohol yielded a clear sensation. This result may imply that there are no pure olfactory stimuli.

Trigeminal sensitivity to contact chemical stimulation: A new method and some results