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Tolerance to an environmental cold challenge in rats is eliminated when cold exposure occurs in a context different from the adaptation context, indicating that learning mechanisms play a role in thermoregulation (Riccio, MacArdy, & Kissinger, 1991). This finding, analogous to outcomes obtained with drug tolerance, was investigated in the present study. Experiment 1 demonstrated that a change in both proximal and distal contextual cues disrupts an established cold adaptation, an outcome consistent with the view that associative processes contribute to the tolerance. In Experiment 2, although cold tolerance persisted over a 7-day retention interval, the disruption of tolerance by a shift in context was attenuated with the delay of testing. This finding suggests that the precise stimulus attributes of the context were forgotten over the interval. Experiment 3 demonstrated that cold-tolerance disruption is due to the actual change in context and not to novelty of the test context. Experiment 4 showed that changing the context associated with each cold exposure impaired the development of tolerance. The results of these experiments provide additional evidence that cold tolerance is regulated at least partially by associative learning processes.

Stimulus conditions influencing the development of tolerance to repeated cold exposure in rats