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In this study we used the trapezoid rotation test to evaluate vestibular function in normal guinea pigs or guinea pigs with peripheral vestibular disorder. Post-rotatory nystagmus (PRN) was recorded on videotape under dark conditions with an infrared charge-coupled device camera. The analysis was performed using the pubic domain NIH Image program, and the horizontal and vertical components were calculated automatically. The mean value of maximum slow phase velocity (MSPV) in the normal guinea pigs and guinea pigs with vestibular disorder was 37.288±9.423 degree/sec and 9.786±2.758 degree/sec respectively. There was a significant correlation between the PRN number and MSPV.We consider that this system makes it possible to evaluate vestibular function in animal models easily and inexpensively.

Evaluation of Vestibular Function in Animal Models with Partial Peripheral Vestibular Disorder.