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The Parenteral route is not routinely used for self– administration of medication. Consequently, other absorptive mucosa is considered as potential sites for drug administration. Transmucosal routes of drug delivery (i.e. the mucosal lining of the nasal, rectal, vaginal, ocular and oral cavity) offer distinct advantages over per oral administration for systematic drug delivery. These advantages include possible by pass of first pass effect, avoidance of pre-systemic elimination within the G.I. tract, and depending on the particular drugs, a better enzymatic flora for drug absorption.

Buccal Patches with Combination drugs: Tramadol and Paracetamol