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Rheumatoid arthritis (RA) is a chronic, inflammatory, systemic autoimmune disease that affects about 1% of the general population in Western countries and is two to three times more common in women than in men. It is characterized by both local and systemic inflammation with elevated plasma concentration of pro-inflammatory cytokines, such as interleukins-6 (IL6), interleukin 1β (IL1β), tumor necrosis factor-α (TNF-α) and acute phase proteins [1]. Conventional treatments for RA, including Nonsteroidal Anti-inflammatory Drugs (NSAID’s), disease modifying anti-rheumatoid drugs (DMARD’s) and corticosteroids, aim to reduce the patient’s pain, joint inflammation; minimize loss of function and decrease the progression of joint damage. However, such treatments are rarely totally effective and some pharmacological therapies have the potential to cause side effects. All anti inflammatory drugs are not antiarthritic because, it does not suppress T-cell and B-cell mediated response. RA is associated with poor nutritional status in relation to various nutrients due to not only because of increased requirements and reduction in their absorption but also due to NSAID’s, DMARD’s and corticosteroids prescribed to alleviate symptoms of this disease [2]. Citrullus colocynthis Schard belongs to the family Cucurbiataceae. It is reported to possess many phytoconstituents like alkaloids, flavonoids, tannins, saponins, triterpenes and glycosides and it is used in the treatment of tumors, as antipyretic [3], antiinflammatory [4], antioxidant [5] and also against hepatic diseases [6], hyperglycemia, Anti diabetic, ulcers, urinary diseases and rheumatism. MATERIALS AND METHODS Collection of plant material Citrullus colocynthis roots were obtained from the local area of Kadapa district, Andhra Pradesh, India. The plant was authenticated by Dr. Madhava chetty, Taxonomist, S.V. University, Tirupathi, India. The Journal of Comprehensive Pharmacy

Anti-arthritic activity of Citrullus colocynthis against Complete Freund’s adjuvant (CFA) induced arthritis in experimental model rats