Open AccessKilling of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein
Author(s) -
Maike Sieben,
Kerstin Herzer,
Maja Zeidler,
Vera Heinrichs,
Barbara Leuchs,
Martin Schüler,
Jan J. Cornelis,
Peter R. Galle,
Jean Rommelaere,
Markus Moehler
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.3819
Subject(s) - oncolytic virus , apoptosis , cancer research , cytotoxicity , biology , promyelocytic leukemia protein , cell culture , programmed cell death , leukemia , acute promyelocytic leukemia , flow cytometry , virology , microbiology and biotechnology , immunology , in vitro , genetics , retinoic acid , tumor cells
To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML).
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