Open AccessEffect of balance Solution on the Peritoneal Membrane in Automated Peritoneal Dialysis
Author(s) -
De los Ríos Tatiana,
Pérez-Martínez Juan,
Portoles Jose,
Lichodziejewska-Niemierko Monika,
Rivera Maite,
Nowicki Michał,
Książek Andrzej,
Tato Ana María,
Bohnhorst Christine,
Feriani Mariano
Publication year - 2016
Publication title -
peritoneal dialysis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.79
H-Index - 83
eISSN - 1718-4304
pISSN - 0896-8608
DOI - 10.3747/pdi.2015.00010
Subject(s) - peritoneal dialysis , medicine , biocompatibility , urology , peritoneal equilibration test , dialysis , peritoneum , membrane , gastroenterology , surgery , continuous ambulatory peritoneal dialysis , chemistry , biochemistry , organic chemistry
Interference of conventional peritoneal dialysis fluids (cPDFs) with peritoneal membrane cell functions may be attributed to the dialysis fluid's low pH, high glucose concentration, and/or the presence of glucose degradation products (GDPs), the last of which leads to higher levels of advanced glycation end-products (AGEs). It has been suggested that the peritoneal membrane might be better preserved by using biocompatible solutions, including cancer antigetn 125 (CA125). This prospective, open-label, multicentre, randomized, controlled, cross-over phase IV study compared the in vivo biocompatibility of a neutral-pH, low-GDP peritoneal dialysis (PD) solution ( balance ) with a cPDF in automated PD (APD) patients. Our study revealed a significantly increased appearance rate and concentration of CA125 in the peritoneal effluent of APD patients treated with the neutral-pH, low-GDP solution balance versus a conventional PD solution.
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