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In patients with inoperable locally advanced or metastatic soft tissue sarcoma, does first-line dose-intensive chemotherapy supported by growth factor or autologous bone marrow or stem-cell transplantation improve response rate, time to disease progression, or survival as compared with standard-dose chemotherapy? What are the effects of first-line dose-intensive chemotherapy supported by growth factor or autologous bone marrow or stem-cell transplantation on toxicity and quality of life?

current oncology

Dose-Intensive Chemotherapy with Growth Factor or Autologous Bone Marrow or Stem-Cell Transplant Support in First-Line Treatment of Advanced or Metastatic Adult Soft Tissue Sarcoma: A Clinical Practice Guideline