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Background: The deterioration of nephrons at an advanced stage of renal disease results to chronic dysfunction of the kidneys, which requires either dialysis treatment or renal transplant. The need to enhance the clearance of byproducts of metabolism from the body during haemodialysis spurred the study. Purpose: To determine Responses of Urea, Creatinine and Uric Acid to Soft Tissue and Passive Mobilization in Patients with Renal Diseases Undergoing Haemodialysis. Method: This study is a randomized controlled clinical trial. The total of 33 participants (23 males and 10 females) was involved in the study. The participants were randomly and consecutively assigned into two groups as they register for haemodialysis. The treatment group (n=16) received the soft tissue and passive mobilisation prior to haemodialysis. The control group (n=17) had only haemodialysis. In each group, the pre and post-dialysis blood samples for determination of plasma concentration of urea, creatinine and uric acid were taken. Data collected were subjected to descriptive statistics, and analyzed using independent t-test. Probability value less than 0.05 was considered statistically significant. SPSS version 17 was used. Result: The results showed that soft tissue and passive mobilisation clinically enhances the reduction (p<0.05) of the plasma concentration of creatinine and uric acid after haemodialysis in patients with renal disease. However, there was no significant reduction (p>0.05) in the plasma concentration of urea compare to the control, probably due to low molecular weight of urea. Conclusion: Soft tissue and passive mobilization enhances fluid kinetics, dislodges metabolites, especially those of high molecular weight such as uric acid, in the interstitial spaces and mobilizes them into the blood stream for clearance. Implication: Soft tissue and passive mobilization could be utilized as an adjunct to haemodialysis in the clearance of by-products of metabolism in relevant patients.