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SUMMARY Clematis chinensis is the root of Clematis chinensis OSBECK and is classified in Ranunculaceae.Clematis chinensis is a traditional medicinal herb possesses analgesic, diuretic, anti-tumorigenic,and anti-inflammatory effects. In this study, the effect of aqueous extract of Clematis chinensisagainst lipopolysaccharide-induced inflammation was investigated in mouse BV2 microglialcells. The aqueous extract of Clematis chinensis at the respective concentration was treated onehour before the lipopolysaccharide treatment in mouse BV2 microglial cells. From the presentresults, pre-treatment with the aqueous extract of Clematis chinensis suppressed prostaglandin E 2 synthesis and nitric oxide production by inhibiting on the lipopolysaccharide-stimulatedcyclooxygenase-2 and inducible nitric oxide synthase expressions in mouse BV2 microglial cells.The present study suggests that Clematis chinensis may offer a valuable mean of therapy for braininflammatory diseases. Key words: Clematis chinensis; Lipopolysaccharide; Cyclooxygenase-2; Inducible nitric oxidesynthase; Prostaglandin E

oriental pharmacy and experimental medicine/oriental pharmacy and experimental medicine

Clematis chinensis suppresses lipopolysaccharide-induced expressions of inducible nitric oxide synthase and cyclooxygenase-2 in mouse BV2 microglial cells