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Potassium isopropoxide, involved in the cycle reaction of the intermediate dehydroester, is an important coupling agent in the production of drug pipemidic acid tablets. Current production problems of potassium isopropoxide by alkali method are the long period, the low productivity and the high energy consumption. To solve these problems, the reactive distillation production process of potassium isopropoxide was studied by simulation calculation and pilot experiment. The results show that the production process of potassium isopropanol is influenced by the separation efficiency and the reaction rate. The number of suitable theoretical plates for the column of azeotropic distillation is 14. The dissolution of solid potassium hydroxide is promoted and the reaction rate is increased, when a small amount of water is added to the raw material. It is found that the water content in the reflux organic phase can be reduced by lowering the liquid temperature in the condenser. It is also observed that suitable process conditions and the new type phase splitter can greatly reduced the production time of each batch of potassium isopropoxide.

Process Optimization and Experimental Study on the Alkaline Production Process of Potassium Isopropoxide