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The determined values of paraoxonase-1 serum concentration in 91 patients with cardiac insufficiency with a preserved ejection fraction with etiology of ischemic cardiopathy showed that this as an antioxidant enzyme may be accepted as a diagnostic biomarker, the assessment of the response to therapy, but also risk in this condition. Reporting circulating values of isozyme to the sex of patients revealed a very good correlation for males, which would confer PON1 specificity of sex to such a condition.

PON-1, Possible Biomarker for Diagnosis But Also for Risk in Diastolic Dysfunction with Preserved Ejection Fraction