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The impact of sucrose and systemic cortisone treatment on the response of dentin was examined in an experimental rat model. After 2 months of a modified diet and/or medication period, the areas of dentin formation and dentinal caries were quantified in the mandibular molars of growing animals. The 60% sucrose diet significantly reduced dentin formation and increased dentinal caries progression. The presence of glucocorticoid medication alone reduced dentin formation. Cortisone medication in combination with sucrose diet further decreased dentin apposition. Rats receiving the control diet positively responded to the dentinal caries by increasing dentin formation to prevent pulpal exposure. The rate of dentine formation was lower in rats with high sucrose diet and predentin area was wider compared to the control group fed normal diet. The enlargement of the predentin region in sucrose diet rats reflects changes in the functionality of the odontoblasts, such as reduction of matrix synthesis and alteration of the mineralization process. These results indicate that the functional alterations in the pulpo-dentinal complex might contribute to dentinal caries progression through systemic mechanism irrespective of the causative factors.Keywords:  diet, sucrose, cortisone, dentin

Evaluation of the Impact Induced by High Dietary Sucrose Concentration and Glucocorticoid Medication on Dentin Formation of Young Rats