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The amniotic membrane is a readily available biomaterial with an important potential for tissue regeneration in dermatology and ophtalmology, with anti-inflammatory and anti-microbial properties. The extracellular matrix of the amniotic membrane is composed mainly of collagen, fibronectin and laminin. The purpose of our study was to investigate the structural modifications of collagen extracellular matrix of amniotic membrane upon interaction with two different antibiotics, frequently used in surgical and postsurgical procedure, respectively ciprofloxacin and gentamicin. SEM micrographs evidenced the ultrastructure features of dried amniotic membrane, with laminar structure, flexible, transparent, with no blood vesels or nerves. FTIR spectroscopy combined with deconvolution techniques was applied with the aim to determine the extent of denaturation upon treatment with different antibiotics. By spectral analysis, we concluded that gentamicin treatment is more favorable compared to ciprofloxacin, as the denaturation process is reflected by the lower sheet/turns ratio of the secondary structure composition.

Assessment of Antibiotic Influence on Structural Modifications of Amniotic Membrane by FTIR Spectroscopy