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The active constituents of natural medicine resources are complicated and in low content, which are difficult to be extracted and separated by general methods. Molecularly imprinted polymers are functional porous materials with molecular-specific recognition sites to a particular target molecule. The molecularly imprinted solid phase extraction has been used as a sample preparation technique for the separation of active constituents from natural medicine resources. The target molecules in a mixture of chemical species can be recognized selectively. In this review, the applications of the molecularly imprinted solid phase extraction for the determination and separation of active constituents (e. g. flavonoids, polyphenols, alkaloids, organic acids, phenylpropanoids, terpenoids, etc. ) from natural compounds in recent years are summarized.

Application of molecularly imprinted solid phase extraction in the separation and determination of active constituents from natural compounds