English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Acute rhinosinusitis treatment and prevention is connected to the rational choice of drug dosage form, which will provide the therapeutic effect and the safety of a drug substance or a drug substance complex. Nasal spray with Enisamium Iodide can be used to nasal congestion relief in acute rhinosinusitis because the active substance has an anti-exudative action. Nasal endoscopy could be used in experimental rhinology as a method for direct pathology visualization and for evaluation of the effectiveness of test drugs.Aim: To substantiate Enisamium Iodide (nasal spray) 10 mg/mL effectiveness on maxillary sinus ostium via nasal endoscopy in rabbits with experimental rhinosinusitis.Methods: As a test object was used Enisamium Iodide (nasal spray). As a reference drug, we used BNO-101. Experimental rhinosinusitis was induced in the 1st day. On the 1st , 15th and 25th days in all groups (four groups, six rabbits in each group), we used nasal endoscopy and semi-quantitative assessment to the result objectivity.Results: The total score in the intact control group was 0 (0÷0) on the 15th and 25th days (physiological state). The total score in the control pathology group was 2.0 (2.0÷2.0) and 2.0 (1.0÷2.0) (severe rhinosinusitis) respectively. The total score in Enisamium Iodide treated group was 2.0 (1.0÷2.0) (severe rhinosinusitis) and 0.0 (0.0÷1.0) (physiological state). The total score in BNO-101 treated group was 2.0 (1.0÷2.0) (severe rhinosinusitis) and 1.0 (1.0÷1.0) (mild rhinosinusitis).Conclusions: Nasal endoscopy can be used as an informative visual method. Enisamium Iodide (nasal spray) has been shown a positive effect by endoscopic evaluation of maxillary sinus ostium and exceeded activity of the reference drug.

Nasal endoscopy prospectsin experimental rhinology: some aspects of enisamium iodide nasal spray effectiveness in rhinosinusitis