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skin aging, manifested as wrinkles, age spots and elasticity degradation. In ultraviolet radiated areas degradation of the collagen results in skin aging 5 because of matrix metalloproteinases (MMPs). These are secreted from dermal fibroblasts and epidermal keratinocytes in response to ultraviolet (UV) radiations. The MMPs activation is the result of secretion of number of cytokines by reactive oxygen 6,7 species in keratinocytes. Oxidative stress also results in formation of different degraded and unstable products like toxic aldehydes and ketones, protein oxidation and DNA mutations. All these results in different pathological conditions in host cells and ultimately leads to premature aging and cancer. The suppression of inflammatory cytokines and inhibition of MMPs is crucial for preventing age 8 related skin deterioration. The matrix metalloproteinase group consist of metzincin super family which comprises of over 20 9,10 different zinc peptidases. This series of enzymes Introduction Astaxanthin is naturally occurring xanthophyll carotenoid originally isolated from lobsters by Kuhn 1 and Sorensen. It is also found in sea foods such as shrimps, crabs and fish. Astaxanthin is a highly antioxidant, anti-inflammatory and anti-cancer agent. Furthermore, it has anti-aging effects and is y 2 used in topical creams as sun blocking agent. Skin is the primary and largest organ of human body and provides protection against several different 3,4 factors including physical, chemical and biological. Physiological and photoaging are mechanisms of Molecular Docking Study of Astaxanthin Derived from Radio-Resistant Bacterium Deinococcus sp. Strain WMA-LM9 to Matrix Metalloproteinase-1, 3 (MMP-1, MMP-3) Wasim Sajjad, Sumra Wajid Abbasi, Liaqat Ali

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Molecular Docking Study of Astaxanthin Derived from Radio-Resistant Bacterium Deinococcus sp. Strain WMA-LM9 to Matrix Metalloproteinase-1, 3 (MMP-1, MMP-3)