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Aim: Our objective in this study is assessment of Mantle Cell Lymphoma International Prognostic Index (MIPI) and biological MIPI (MIPI-B) scores as prognostic markers based on real-life data of patients diagnosed with mantle cell lymphoma (MCL) in Turkey. Materials and methods: A total of 54 patients above 18 years of age who were diagnosed with MCL were included in the study. Patients’ demographical data, chronic diseases, treatments, and outcomes were reviewed. Cox regression analysis was used for evaluation of potential risk factors that were statistically associated with mortality and Kaplan-Meier analysis was used for evaluation of survival. Results: A total of 54 patients, 35 male and 19 female, who were diagnosed with MCL were included in the study. Mean age was 62.2 years and mortality rate was 44.4% (n: 24). Among the deceased patients, beta-2 microglobulin level, CNS involvement, presence of B symptoms, bone marrow involvement (87.0% vs. 26.7%), and rate of extranodal involvement (100% vs. 20%) were determined to be high. Among the surviving patients, the rate of patients whose initial response to treatment was complete remission was higher (66.7% vs. 25%). Among the deceased patients, the median Ki-67 proliferation index level (70 vs. 22.5), median International Prognostic Index level (4.5 vs. 3), median MIPI level (8 vs. 5), and median MIPI-B level (8.1 vs. 4. 1) were high. Conclusion: This study is the first study demonstrating that MIPI and MIPI-B scores are important prognostic markers in patients diagnosed with MCL in the Turkish population.

Prognostic Significance of MIPI and MIPI-B Scoring Systems for Mantle Cell Lymphoma in the Turkish Population