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Nanoparticles functionalized with targeting ligands have been proposed as effective carriers for the selective delivery of diagnostic or therapeutic reagents to desired locations in the body. However protein coronas formed on the surface of such functionalized nanoparticles may affect their targeting efficiency when introduced into physiological environment. Here, Zinc Doped Iron Oxide Nanoparticles (Zn0.4Fe2.6O4 NPs) were prepared, and functionalized with Cyclic arginine-glycine-aspartic Acid (c(RGDyK)) peptide to target U87MG cells.

Targeting Ability of c(RGDyK)-Functionalized Nanoparticles is Inhibited by Protein Coronas