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Alzheimer's Disease (AD) is a neurodegenerative disease that has an insidious onset and slow progression. Despite the vast amount of work done on AD, its pathogenesis is still unclear, resulting in a lack of specific treatments. This deficit is currently a large focus for both Traditional Chinese Medicine (TCM) as well as Western medical research. Although a clear mechanism for AD is still missing, the current “Aβ cascade” theory is a core component of current thinking regarding AD pathogenesis . One school of thought holds that β-amyloid (Aβ) aggregation is a key mechanism in AD pathogenesis, with Aβ accumulation and deposition in the brain being one of the main pathological changes in AD patients.

Effect of Chinese Herbal Medicine Xixin Decoction on Aβ42 and its Regulatory Enzymes in APP/PS1 Double Transgenic Murine Brain