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Necrotizing enterocolitis (NEC) is the most common serious acquired disease of the gastrointestinal tract in preterm infants. Although it can occur in full-term neonates, almost 90% of all cases occur in premature infants. Both incidence and case fatality rates increase with decreasing birth weight and gestational age. The majority of cases occur in very low birth weight infants with an incidence of approximately 6 to 7%. In ELBW infants reported NEC rates range between 10 and 11%.

Routine Probiotics Decrease the Incidence of Necrotizing Enterocolitis in Extremely Low Birth Weight Infants < 1000 Grams