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Medulloblastoma is an aggressive tumor; grade IV of the WHO classification that develops in the cerebellum, mostly linked to infancy and adolescence. It can be classified histologically and molecularly in different subtypes. Morphologically it can be divided into classical, desmoplastic/nodular, anaplastic, and large cell medulloblastoma. Molecularly, there are four groups: Wnt, Shh (sonic hedgehog), group 3 (mainly linked to MYC amplification), and group 4 (for unclassified tumors).

Inhibition of the Sonic Hedgehog Pathway by Cyclopamine or GLI1 siRNA Reduces In Vivo Tumorigenesis of Human Medulloblastoma Cells Xenotransplanted to Immunodeficient Nude Mice