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The author of this paper, in order to diagnose the imbalance of connective tissue metabolism, has analyzed the results of laboratory tests of blood and urine according to biochemical parameters of thepatients with closed craniocerebral injury (CCI) with diff erent severity and has established their clinical and diagnostic value. 100 children who had closed craniocerebral trauma were examined. There were 79 boys (79 %) and 21 girls (21 %), aged from 3 to 17 years among them. Distribution of children into groups was conducted according to the clinical formsof craniocerebral trauma: Group I — closed craniocerebral trauma, cerebral concussion — 50 children (50 %), average age (14,6 ± 2,5) years; Group II — closed craniocerebral trauma with cerebral contusionof moderate severity — 20 children (20 %), average age (13.5 ± 4.5 years); Group III —closed craniocerebral trauma with severe cerebral contusion — 30 children (30 %), average age (14.5 ± 3.5 years). Chondroitin sulfates were determined in the blood serum of patients — according to the М. Németh-Csóka method in the modifi cation of L. I. Slutskyi, fraction of glycosaminoglycans (GAG). The content of oxyproline was determinedin the urine — by the reaction with chloramine-B, uronic acids — by thereaction with carbazole. In case of mild CCI (cerebral concussion),the indicators of biochemical studies of the blood and urine remained within the normal range, while with the increase in the severity of the injury, we observed an increase in chondroitin sulfate, and a decrease in the level of general GAG, its II and III fractions, and an increase in oxyproline in the urine, indicating the dysgenesia of the connective tissuemetabolism and which may be the basis for the unfavorable course of closed craniocerebral injury of children during the rehabilitation period.Detection of changes in the connective tissue metabolism allows additionally predict the course of the disease in the period of rehabilitation and the possibility of recovery of children after CCI.Key words: children, craniocerebral injury, connective tissue dysgenesia, mucopolysaccharides, oxyproline.

Specifi c features of connective tissuing metabolism of children with closed craniocerebral injury