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The cell nucleus, apart from heterochromatin, i.e. a complex of DNA and histone proteins, contains structures called nuclear bodies. These small, usually circular objects, "suspended" in nucleoplasm, consist of proteins or proteins and non-coding RNA. Currently, several types of such structures are known. This article presents current state of knowledge about the bodies called nuclear speckles or interchromatin granule clusters. Observed for the first time by Roman y Cajal in neurons, but present in all types of cells, they are considered as storage and modification sites for mRNA splicing factors. The latest research presented in this article suggests that their participation in RNA metabolism is more complex. This is also evidenced by reports of the role of nuclear speckles in hereditary diseases caused by repetitions of trinucleotides, including those with neurological effects.

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