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The human microbiome is one of the most densely populated ecosystems known to humankind. Due to this density, the proximity of cells in the human gut favors certain mechanisms of acquiring AMR, e.g., mutation and horizontal gene transfer (HGT). AMR via HGT is referred to herein as hAMR (antimicrobial resistance via horizontal gene transfer). Also, the human microbiome is an open system; thus, moment-to-moment, the human microbiome is involved in numerous encounters that may result in large populations of diverse cells becoming singularly resistant or cluster resistant to antibiotics. Devising biostatistical and mathematical models to depict the factorial correlations within this system is deemed fundamental [1-3].

Epidemiological Consideration: The Application of Quantitative Biology in the Analysis of Mortality Rates Affected by Antimicrobial Resistance