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PLND is still the gold standard for LN staging in clinically localized prostate cancer. The diagnostic accuracy of available imaging procedures is quite inferior to the histological verification of LN metastases. The LN status is a crucial prognostic factor in prostate cancer. Presence and extension of LNI is associated with an increased risk of systemic dissemination and progression of the disease. Moreover, the role of PLND as a therapeutic intervention has been the focus of renewed interest. Several reports indicate that PLND improves biochemical relapse-free survival, especially in patients with minimal lymphatic dissemination [1,2]. LNI prevalence is directly related to the number of dissected LNs and extent of the PLND [3,4]. There is general consensus that an ePLND achieves the highest staging accuracy. However, the rate of complications rises along with the number of LNs removed [5-7].

sm journal of urology

Radioisotope Guided Sentinel Lymph Node Dissection in Prostate Cancer: Rate of Lymph Node Involvement Depending on Preoperative Tumor Characteristics in More Than 2,100 Patients