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Lipids have a wide variety of functions in living cells, as building blocks, energy storage, as well as signaling and cell communication [1,2]. Lipid metabolism may be altered in cancer cells and some of these changes have been proposed to play a role in carcinogenesis and cancer progression [3]. Arachidonic Acid (AA), a 20-carbon polyunsaturated fatty acid, gives rise to many bioactive lipids collectively called eicosanoids. It cannot be synthesized de novo by animal cells and is obtained from dietary sources [4]. AA is metabolized through three key metabolic pathways, cyclooxygenases, producing prostaglandins, and Lipoxygenases (LOX), producing leukotrienes, as well as cytochrome P450 (CYP 450) [5].

Method Development by Design of Experiments for Quantification of Lipoxygenase Metabolites in Human Cancer Cells with UPLC-MS/MS